In Vitro Chemoresistance and Chemosensitivity Assays
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چکیده
Background/Overview A variety of chemosensitivity and chemoresistance assays have been clinically evaluated in human trials. All assays use characteristics of cell physiology to distinguish between viable and nonviable cells to quantify cell kill following exposure to a drug of interest. With few exceptions, drug doses used in the assays are highly variable depending on tumor type and drug class, but all assays require drug exposures ranging from several-fold below physiologic relevance to several-fold above physiologic relevance. Although a variety of assays examine chemosensitivity or chemoresistance, only a few are commercially available. Available assays are outlined as follows.
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Medical Policy Subject: Tumor Chemoresistance and Chemosensitivity Assays
Tumor chemoresistance and chemosensitivity assays have been investigated as a means of predicting tumor response to various chemotherapies. Tumor chemoresistance assays are focused on identifying resistant drugs. Tumor chemosensitivity assays are intended to predict the sensitivity of various tumors to chemotherapeutic agents. These assays have been proposed for use by oncologists to select che...
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